@TakeiDaloui I don't think Aqua knows that Ruby is his former patient. The closest we've seen him come to realizing is back from when they were kids and she responded to being called Serena, but he didn't seem to notice. If he does know, it's something that we haven't seen yet as readers
Kan does a really great job at showing how differently depression affects everyone. Actually, half of the cast shows how it and alienation can have different effects. Loving it so far.
Isaac is one of my favorite characters. I highly doubt that he had anything but selfish intentions allowing himself to die, but it's just so entertaining to watch him do his work.
@Colomopri For girls, it's way more common to get than with guys and can happen pretty easily after sex. If they don't go pee after sex, it ends up burning a lot for the next few weeks.