@ horsewithnoname
It is harsh. To be a doctor you either need to enjoy the human contact as negative as it may be, to enjoy the authority it gives or, albeit more wickedly, you need to like to brag... a lot. If you don't fulfill any of those conditions, then the profession just consumes you and you either become apathetic or burned out with stress. It depends on what you're specialized into, but the stressful ones have their share of suicides every year. Anesthesiologists are high up there on the list because of how easy it's for them to procure...painless ways to pass on. Also it's quite up there in drug addiction rates among physicians .
@ ghostkun
Widely known rumor back in the day. Supposedly the author was being held in palliative care in an university hospital, and he was known for being outspoken about Japan's healthcare system besides the manga. Supposedly he was denied pain medication under flimsy reasoning. Covered under wraps in the end.