Rape: A total of three times
1) At the beggining the protagonist is taken advantage of for being drunk. I see it as rape but well, since it was drawn nicely you may not take it as bad.
2) It didn't got as far a penetration but there was fingering and drugging involved.
3) A man forcing himself on a kid. It was treated as a joke which is disgustingly disturbing. It wasn't explicit but you can see him about to touch the kid.